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    • Volume 2, Issue 1 (September 2020)
  • Open Access

    An Overall Review on Tinospora Cordifolia

    Gundu Anusha1, Abbaraju Krishna Sailaja1*
    DOI: https://doi.org/10.31058/j.em.2020.21001DOI: https://doi.org/10.31058/j.em.2020.21001, PP: 1-6, Pub.Date: Aug 5, 2020

    Abstract | References Full Paper: PDF (Size:33KB), Downloads:599

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    T. cordifolia has been used in Ayurvedic preparations for the treatment of various ailments throughout the centuries. It is used as a rasayana to improve the immune system and body resistance against infections. The whole plant is used medicinally; however, the stem is approved for use in medicine as listed by the Ayurvedic Pharmacopoeia of India. This is due to higher alkaloid content in the stems than in the leaves. In this review detailed description of the plant was given along with its medicinal properties and applications in various dosage forms.

    T. cordifolia has been used in Ayurvedic preparations for the treatment of various ailments throughout the centuries. It is used as a rasayana to improve the immune system and body resistance against infections. The whole plant is used medicinally; however, the stem is approved for use in medicine as listed by the Ayurvedic Pharmacopoeia of India. This is due to higher alkaloid content in the stems than in the leaves. In this review detailed description of the plant was given along with its medicinal properties and applications in various dosage forms.

  • Open Access

    Correlation between Fingerprint Patterns and Sex, Genotype, Intelligence Quotient, and Handedeness among Nigerian Senior Secondary School Students

    Ojo Gideon Babatunde1*, Adedokun Precious Olufunmilayo1, Adedokun Musiliu Oluwaseun2
    DOI: https://doi.org/10.31058/j.em.2020.21002DOI: https://doi.org/10.31058/j.em.2020.21002, PP: 7-19, Pub.Date: Aug 5, 2020

    Abstract | References Full Paper: PDF (Size:277KB), Downloads:654

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    Introduction and Background: Fingerprints – a naturally occurring feature in humans that appear as carvings, are so unique to each person that ‘no two people have the same fingerprints’. They have been studied as far back as centuries ago and even till date and are basically classified into: arch, loop and whorl. Methods: In this work, the relationship between sex, blood groups, handedness and intelligence quotient (IQ) of 296 senior students of a secondary school in Ibadan, Oyo State, Nigeria, vis-à-vis their fingerprint patterns was studied using the ink method: The fingerprints were impressed on the questionnaires provided, required information bordering on the aforementioned parameters was provided and IQ test attempted. All the parameters were then analyzed in relation to the fingerprints. The percentages determined were fed into Microsoft Excel 2010 for statistical analyses and further presented as bar charts. The IQ scores were categorized based on the Wechsler scale. Results: Subjects with average intelligence had the highest number of all the fingerprint types. Males had fewer arches, more loops and fewer whorls than females. Genotype AA and blood group A were the most dominant in the blood grouping and they exhibited the highest number of arches, loops and whorls. Similarly, highest number of all the fingerprint types was observed in right-handed subjects. The ranking order of fingerprints in the overall population sample was: loops > whorls > arches. Conclusions: This research has been conducted as an instigator for fingerprints to be innovated and further applied, especially in Nigeria.

    Introduction and Background: Fingerprints – a naturally occurring feature in humans that appear as carvings, are so unique to each person that ‘no two people have the same fingerprints’. They have been studied as far back as centuries ago and even till date and are basically classified into: arch, loop and whorl. Methods: In this work, the relationship between sex, blood groups, handedness and intelligence quotient (IQ) of 296 senior students of a secondary school in Ibadan, Oyo State, Nigeria, vis-à-vis their fingerprint patterns was studied using the ink method: The fingerprints were impressed on the questionnaires provided, required information bordering on the aforementioned parameters was provided and IQ test attempted. All the parameters were then analyzed in relation to the fingerprints. The percentages determined were fed into Microsoft Excel 2010 for statistical analyses and further presented as bar charts. The IQ scores were categorized based on the Wechsler scale. Results: Subjects with average intelligence had the highest number of all the fingerprint types. Males had fewer arches, more loops and fewer whorls than females. Genotype AA and blood group A were the most dominant in the blood grouping and they exhibited the highest number of arches, loops and whorls. Similarly, highest number of all the fingerprint types was observed in right-handed subjects. The ranking order of fingerprints in the overall population sample was: loops > whorls > arches. Conclusions: This research has been conducted as an instigator for fingerprints to be innovated and further applied, especially in Nigeria.

    • Volume 1, Issue 2 (December 2018)
  • Open Access

    Variable and Attribute Control Charts in Trend Analysis of Active Pharmaceutical Components: Process Efficiency Monitoring and Comparative Study

    Mostafa Essam Eissa1*
    DOI: 10.31058/j.em.2018.11003DOI: 10.31058/j.em.2018.11003, PP: 31-44, Pub.Date: Jun 30, 2018

    Abstract | References Full Paper: PDF (Size:2317KB), Downloads:2262

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    Assessment of pharmaceutical product quality is important prerequisite to justify safe and effective release of the medicinal dosage form to the drug market. However, without rigorous implementation of good manufacturing practice (GMP), routine quality control testing may be not adequate to conclude compliance with reproducible procedures. Accordingly, the current study aimed to investigate manufacturing quality of pharmaceutical product batches through monitoring assay results and trends retrospectively for three components of the active ingredients using two types of control charts and to compare the value of each in-process monitoring. This product was manufactured in a pharmaceutical firm and subjected to the assay (expressed as relative potency to the claimed labeled dose per tablet) in quality control laboratory. The active components are Paracetamol (Acetaminophen) (Pa), Chlorpheniramine Maleate (CM) and Pseudoephedrine Hydrochloride (PH). General performance and trend of the studied batches were compared using Individual-Moving Range and Laney U΄ chart which were constructed using statistics software. Box-and-Whisker diagram that was constructed for the assay of the three active constituents showed that CM relative potency was significantly higher than Pa and PH using ANOVA (p<0.05). Capability analysis showed that Pa and PH assays have met the requirement of analysis. In contrast to CM potency which demonstrated a failure to be maintained within the specification window level as strong shift outside the upper border (right drift) could be observed. Both types of control charts variable (Individual-Moving Range) and attribute (Laney U΄) showed same control limits. But Individual-Moving Range was more sensitive in detection of out-of-control states.

    Assessment of pharmaceutical product quality is important prerequisite to justify safe and effective release of the medicinal dosage form to the drug market. However, without rigorous implementation of good manufacturing practice (GMP), routine quality control testing may be not adequate to conclude compliance with reproducible procedures. Accordingly, the current study aimed to investigate manufacturing quality of pharmaceutical product batches through monitoring assay results and trends retrospectively for three components of the active ingredients using two types of control charts and to compare the value of each in-process monitoring. This product was manufactured in a pharmaceutical firm and subjected to the assay (expressed as relative potency to the claimed labeled dose per tablet) in quality control laboratory. The active components are Paracetamol (Acetaminophen) (Pa), Chlorpheniramine Maleate (CM) and Pseudoephedrine Hydrochloride (PH). General performance and trend of the studied batches were compared using Individual-Moving Range and Laney U΄ chart which were constructed using statistics software. Box-and-Whisker diagram that was constructed for the assay of the three active constituents showed that CM relative potency was significantly higher than Pa and PH using ANOVA (p<0.05). Capability analysis showed that Pa and PH assays have met the requirement of analysis. In contrast to CM potency which demonstrated a failure to be maintained within the specification window level as strong shift outside the upper border (right drift) could be observed. Both types of control charts variable (Individual-Moving Range) and attribute (Laney U΄) showed same control limits. But Individual-Moving Range was more sensitive in detection of out-of-control states.

  • Open Access

    Fetal Weight Estimation in Case of Missing Data

    Loc Nguyen1* , Thu-Hang T. Ho2
    DOI: 10.31058/j.em.2018.12004DOI: 10.31058/j.em.2018.12004, PP: 45-65, Pub.Date: Dec 17, 2018

    Abstract | References Full Paper: PDF (Size:129KB), Downloads:1397

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    Fetal weight estimation before delivery is important in obstetrics, which assists doctors diagnose abnormal or diseased cases. Linear regression based on ultrasound measures such as bi-parietal diameter (bpd), head circumference (hc), abdominal circumference (ac), and fetal length (fl) is common statistical method for weight estimation. There is a demand to retrieve regression model in case of incomplete data because taking ultrasound examinations is a hard task and early weight estimation is necessary in some cases. In this research, we proposed so-called regression expectation maximization (REM) algorithm which is a combination of linear regression method and expectation maximization (EM) method to construct the regression model when both ultrasound measures and fetal weight are missing. The special technique in REM is to build parallelly an entire regression function and many partial inverse regression functions for solving the problem of highly sparse data, in which missing values are fulfilled by expectations relevant to both entire regression function and inverse regression functions. Experimental results proved resistance of REM to incomplete data, in which accuracy of REM decreases insignificantly when data sample is made sparse with loss ratios up to 80%.

    Fetal weight estimation before delivery is important in obstetrics, which assists doctors diagnose abnormal or diseased cases. Linear regression based on ultrasound measures such as bi-parietal diameter (bpd), head circumference (hc), abdominal circumference (ac), and fetal length (fl) is common statistical method for weight estimation. There is a demand to retrieve regression model in case of incomplete data because taking ultrasound examinations is a hard task and early weight estimation is necessary in some cases. In this research, we proposed so-called regression expectation maximization (REM) algorithm which is a combination of linear regression method and expectation maximization (EM) method to construct the regression model when both ultrasound measures and fetal weight are missing. The special technique in REM is to build parallelly an entire regression function and many partial inverse regression functions for solving the problem of highly sparse data, in which missing values are fulfilled by expectations relevant to both entire regression function and inverse regression functions. Experimental results proved resistance of REM to incomplete data, in which accuracy of REM decreases insignificantly when data sample is made sparse with loss ratios up to 80%.

    • Volume 1, Issue 1 (September 2018)
  • Open Access

    Infrared Thermography of Cutaneous Integument of Biological Object

    Volodymyr Maslov1*, Svitlana Nazarchuk2 , Kostiantin Bozhko3, Ievgen Venger4 , Vadim Dunaevskii5, Volodymyr Timofeev6 , Vitalyi Kotovskii7
    DOI: 10.31058/j.em.2018.11001DOI: 10.31058/j.em.2018.11001, PP: 1-11, Pub.Date: Mar 2, 2018

    Abstract | References Full Paper: PDF (Size:876KB), Downloads:1945

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    The work presents the results of research on thermometry of cutaneous integument of biological objects, using the method of remote infrared thermography. The process of evaporation of drops of sweat during physical loading has been simulated in imitation of evaporation of drops of water. For the first time, research resulted in time dependence of the temperature of drops of water (sweat) with convective and diffuse mechanisms of a heat and mass exchange with the ambient air. Research results can be applied in experimental medicine for controlling process of athletes training.

    The work presents the results of research on thermometry of cutaneous integument of biological objects, using the method of remote infrared thermography. The process of evaporation of drops of sweat during physical loading has been simulated in imitation of evaporation of drops of water. For the first time, research resulted in time dependence of the temperature of drops of water (sweat) with convective and diffuse mechanisms of a heat and mass exchange with the ambient air. Research results can be applied in experimental medicine for controlling process of athletes training.

  • Open Access

    Early Fetal Weight Estimation with Expectation Maximization Algorithm

    Loc Nguyen1*, Thu-Hang T. Ho2
    DOI: 10.31058/j.em.2018.11002DOI: 10.31058/j.em.2018.11002, PP: 12-30, Pub.Date: May 7, 2018

    Abstract | References Full Paper: PDF (Size:132KB), Downloads:2028

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    Fetal weight estimation before delivery is important in obstetrics, which assists doctors diagnose abnormal or diseased cases. Linear regression based on ultrasound measures such as bi-parietal diameter (bpd), head circumference (hc), abdominal circumference (ac), and fetal length (fl) is common statistical method for weight estimation but the regression model requires that time points of collecting such measures must not be too far from last ultrasound scans. Therefore this research proposes a method of early weight estimation based on expectation maximization (EM) algorithm so that ultrasound measures can be taken at any time points in gestational period. In other words, gestational sample can lack some or many fetus weights, which gives facilities to practitioners because practitioners need not concern fetus weights when taking ultrasound examinations. The proposed method is called dual regression expectation maximization (DREM) algorithm. Experimental results indicate that accuracy of DREM decreases insignificantly when completion of ultrasound sample decreases significantly. So it is proved that DREM withstands missing values in incomplete sample or sparse sample.

    Fetal weight estimation before delivery is important in obstetrics, which assists doctors diagnose abnormal or diseased cases. Linear regression based on ultrasound measures such as bi-parietal diameter (bpd), head circumference (hc), abdominal circumference (ac), and fetal length (fl) is common statistical method for weight estimation but the regression model requires that time points of collecting such measures must not be too far from last ultrasound scans. Therefore this research proposes a method of early weight estimation based on expectation maximization (EM) algorithm so that ultrasound measures can be taken at any time points in gestational period. In other words, gestational sample can lack some or many fetus weights, which gives facilities to practitioners because practitioners need not concern fetus weights when taking ultrasound examinations. The proposed method is called dual regression expectation maximization (DREM) algorithm. Experimental results indicate that accuracy of DREM decreases insignificantly when completion of ultrasound sample decreases significantly. So it is proved that DREM withstands missing values in incomplete sample or sparse sample.