Education Journal, Vol. 3, Issue 1, Mar  2020, Pages 9-15; DOI:

Role of 3 Atypical Infections (B. Pertussis, C. Pneumonia, M. Pneumonia) in Cases with Prolonged Cough (> 2 weeks): A Cross Sectional Study in Tehran, Iran

, Vol. 3, Issue 1, Mar  2020, Pages 9-15.


Anahita Izadi 1 , Samileh Noorbakhsh 2* , Zahra Movahedi 3 , Sarvenaz Ashouri 4

1 Department Pediatric Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran

2 Pediatric & Research Center of Pediatric Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

3 Department Pediatric infectious Diseases, Qom University of Medical Sciences, Qom, Iran

4 ENT and Head and Neck Research Center and Department, Iran University of Medical Sciences, Tehran, Iran

Received: 6 November 2019; Accepted: 15 January 2020; Published: 13 February 2020

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Chronic cough is a worldwide problems caused by both usual and unusual bacteria. In present study we have searched the atypical organisms; Bordetella Pertussis, Clamydia Pneumonia, Mycoplasma Pneumonia in nasopharyngeal secretion of cases with  prolonged  cough (>2weeks) by Real time PCR. In a prospective cross sectional study we selected 170 children with prolonged cough (>2 weeks) and their close contact persons including 45.9% male and 54.1% female with mean age 27.3±23.8 years, during 2008-2010 in Rasoul Akram Hospital  a reffering hospital in Tehran, Iran .We searched DNAs of 3 atypical infection (C. pneumonia , M. Pneumonia ,and B. pertussis)  by Real time PCR in nasopharyngeal secretion of  cases. Fever seen in 50% of cases, 34.3% of cases had contacted with other cases with prolonged cough, abnormal chest x-ray detected in 61.6%. Other symptoms (convulsion, conjunctional hemorrhage …) except the chronic cough reported in 67.6% of cases. C. pneumonia and B. pertussis detected in 4.8% of cases but M. pneumonia DNA had not found in any cases. As conclusion, C. pneumonia and B. pertussis have a minor role (2.4%; 2.4%) in patients with prolonged cough. (>2weeks) .Most positive cases had previous contact, 50% was febrile and had abnormal chest X ray. Direct detection of Chlamydia pneumonia by polymerase chain reaction on nasopharyngeal aspirates is highly correlated with active infection .In the late stages of prolonged cough serological testing may be more beneficial for obtaining a microbiological diagnosis.


Chronic Cough, B. pertussis, C. Pneumonia, M. Pneumonia, Real Time- PCR


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